bite away®

Principle of Function


This is how bite away® works

bite away®

The original heat pen

bite away® is the original heat pen, which provides effective and long-lasting relief from itching. How does bite away® work?

If you’re bitten or stung the insect’s saliva triggers an immune reaction in the skin. Immune cells are activated and histamine released. Histamine can then bind to the nerve cell receptors. The affected area of skin can start to itch. bite away® can alleviate this skin reaction with concentrated heat. This is called local heat therapy and is based on two potential modes of action.

Mode of action 1

Heat stimulus as counter stimulus

Inhibition of the neuronal signalling pathway for itching can be achieved by a targeted counter stimulus using heat-related activation of the TRPV-1 receptors.1 In simple terms, the application of heat acts as a “counter stimulus” on the nerve cells in the skin. This counter stimulus can inhibit transmission of the itching signal to the brain and thus alleviate the perception of itching.

Mode of action 2

Reduced histamine release

There is also a second possible mechanism of action. Studies have shown that the application of concentrated heat can have a positive effect on various immune reactions. It is assumed that inhibition (heat shock) of the mast cells reduces the release of histamine and other inflammatory mediators (in vitro).2 Reduced histamine release can lead to relief from the sensation of itching.

bite away® applies heat therapy

The original heat pen bite away® applies targeted heat to the skin. It was demonstrated in a clinical study with mosquitoes that bite away® can provide long-lasting relief from itching in as little as one minute4. In a real-life observational study, it was demonstrated that one application is generally enough to stop the itching3.


1: Yosipovitch G, et al., 2005
2: Greaves MW, Mongar JL., 1968
3: Müller et al., Clin Cosmet Investig Dermatol. 2011; 4:191-196
4: Prospective, randomised, placebo-controlled observational study, clinical study conducted at the proDERM Institute, in 2019.