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HEAT REALLY WORKS!
This is how bite away® works
bite away®: The original heat pen
bite away® is the original thermal pen for bites and stings which can provide effective and lasting relief of itching from insect bites and stings.
How does bite away® work?
In the case of an insect bite, the insect’s saliva triggers an immune reaction in the skin. Immune cells are activated and a natural chemical histamine is released by the body.
The histamine can then bind to the receptors of the nerve cells. Itching can develop at the affected skin site. bite away® can relieve this reaction with concentrated heat. This is known as local heat therapy which is based upon two possible mechanisms of action.
Mechanism of action 1: Counter irritation with heat stimulus
Through targeted counter-pain by means of heat-related activation of the TRPV-1 receptors, inhibition of the neuronal itch signalling pathway can be achieved.1 Simply put, the application of heat acts like a “counter-irritant” on the nerve cells of the skin. This counter irritation can inhibit the transmission of the itching signal to the brain and thus relieve the sensation and annoyance of itching.
1: Yosipovitch G, Fast K, Bernhard JD. Noxious heat and scratching decrease histamine-induced itch and skin blood flow. J Invest Dermatol. 2005 Dec;125(6):1268-72.
Mechanism of action 2: Decreased histamine release
In addition, there is a second possible mechanism of action. Studies have shown that the application of concentrated heat can have a positive influence on various immune reactions. It is assumed that through inhibition (heat shock) of the mast cells, the release of histamine and other inflammatory mediators is decreased (in vitro).2 A decreased release of histamine can lead to relief of the itching sensation.
2: Greaves MW, Mongar JL. The mechanism of anaphylactic histamine release from rabbit leucocytes. Immunology. 1968 Nov;15(5):743-9.
bite away® applies heat therapy
The original insect bite heat pen applies targeted heat to the skin. In a clinical study with bite away®, it was shown that it can provide lasting relief of itching in just one minute. In a real-life observational study, it was able to be shown that, in general, one application is enough to stop the itching.3
3: Müller C, Großjohann B, Fischer L. The use of concentrated heat after insect bites/stings as an alternative to reduce swelling, pain, and pruritus: an open cohort-study at German beaches and bathing-lakes. Clin Cosmet Investig Dermatol. 2011;4:191-6.
bite away®
The original heat pen
Get your own bite away® now. After just one application, the original bite-and-sting pen can provide lasting relief of itching from insect bites and stings within one minute. No more creams or annoying smearing. It has a completely chemical-free effect. Designed, engineered & made in Germany.
